What is ViTa ?
ViTa is a database which collects virus data from miRBase and ICTV, VirGne, VBRC.., etc, including known miRNAs
on virus and supporting predicted host miRNA targets by miRanda and TargetScan. ViTa also provide effective annotations,
including human miRNA expression, virus infected tissues, annotation of virus and comparisons. Additionally, a
multiple functions and graphical web interface are designed and implemented to help users to investigate the microRNA
roles in viral existence. ViTa is developed by Bidlab(2005), and will be maintain and update. More and more disease is
supported in future.
Data Generation Flow
miRNAs are produced from viruses
Virus can produce miRNAs after infecting. The main function may escape host T cell, and reduce its
expression, but not infective activity, and exist synchronous. For example, HIV is a famous virus
which causes AIDS, can encode nef miRNAs that repress HIV's T antigen, but maintain its' infection.
|Relationship between miRNA and virus
MicroRNAs have multiple roles in regulation
of post-transcripts, which are ~ 22 nt long non-coding RNAs
found in all metazoan eukaryotes. Now, miRNAs are also produced
from and viruses in mammalian. The possible role
is to assist in escaping from host immunity mechanism by decreasing
its activity (Omoto, Ito et al. 2004) or regulating host mRNAs.
Under powerful function of microRNAs/siRNAs in mammals, we try to
collect virus data from other databases, and predict putative
miRNAs on viruses to look for potential relationships between
existence of influenza viruses and miRNAs, which are produced
from its own or helper viruses.
Infection of HIV
Why to find host miRNA targets on virus ?
Recently, miRNAs are discovered to affect viral existence by targeting to viruses after entering hosts,
such as hepatitis C virus(Jopling, Yi et al. 2005) and HIV(Hariharan, Scaria et al. 2005). Human miR-122a
appears to assist HCV replicate in host by targeting to 3íŽ UTR on HCV genome. Oppositely, HIV is suppressed
by targeting several genes by human microRNAs. These tell us human microRNAs as regulators for affecting
life cycle of viruses in host. And the relationship between viruses and host miRNAs is worthy to further
research for potential therapy.
The database will be developed as follows. (i) It will be made to support miRNA annotations including miRNA
genes and miRNA targets on viruses for other hosts, not only human, mouse, rat and chicken; (ii) The ViTa data
will be further analyzed to support the miRNAs involved in the combinatorial control of the expression of
infecting viruses. (iii) A complete relationship between viruses and diseases are contained later.
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